Poster (download)
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Gorchakov V.N.1, Gorchakova O.V.2, Kolossova N.G.3, Demchenko G.A.4
1Research Institute of a clinical and experimental Lymphology – branch of Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Science, vgorchak@yandex.ru
2Research Institute of a clinical and experimental Lymphology – branch of Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Science, vgorchak@yandex.ru
3Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Science, kolosova@bionet.nsc.ru
4Institute of Physiology of Human and Animals of Committee of Science of the Ministry of Education and Science of the Republic of Kazakhstan, georgiidemchenko@mail.ru
The research purpose is to estimate the structural organization of lymph nodes of different localization at natural (physiological) and premature aging respectively at OXYS and Wistar rats. We used a morphological method of a research. The age-induced changes of lymphoid tissue of Wistar and OXYS rats differ with type of the immune response and morphological variant of lymph nodes structure. The immune response on humoral type is formed in mesenteric and inguinal lymph nodes, and the immune response on cellular type is formed in a tracheobronchial lymph node. We noted reduction of structures of cortical substance, especially lymphoid follicles and a paracortex, and expansion of medullary substance in a lymph node of OXYS rats. Lymph nodes are subject big morphological changes at rats of OXYS, than at old rats of Wistar. Observed changes of structure of lymph nodes of rats of OXYS are a morphological equivalent of premature aging and confirms early decrease of a drainage and immune function of lymph nodes.