Accepted_test

Discovery of Promising Functional Motifs as Key Candidates for Multi-Antiviral Therapy

by Sukhanova Xenia | Roland G. Huber | 1) Applied Genomics Laboratory, SCAMT Institute, ITMO University, Lomonosova street 9, Saint Petersburg 191002, Russia; 2) Biomolecular Function Discovery, Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Matrix #07-01, Singapore, 138671, Singapore | Biomolecular Function Discovery, Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Matrix #07-01, Singapore, 138671, Singapore

Abstract ID: 389

Event: BGRS-abstracts

Sections: [Sym 1] Section “Regulatory genomics”

The escalating threat posed by diverse viruses such as Zika, Dengue, SARS-CoV-2, and Chikungunya underscores the pressing need for adaptable antiviral strategies. Existing approaches often lack versatility, targeting specific viruses and leaving a critical gap in developing interventions effective across multiple infections. This study addresses this challenge by employing the SPLASH method, renowned for its comprehensive examination of RNA-RNA interactions, to identify shared intervention regions across a spectrum of viruses. Utilizing a multifaceted methodology, including orthogroup clustering, functional annotation, and advanced sequence analysis techniques, we identified promising orthogroup-specific viral motifs (OG0002480 and OG0009649). These motifs demonstrate remarkable broad-spectrum efficacy against various viral genomes, presenting potential targets for versatile antiviral therapy. Exploration of cellular mechanisms associated with these motifs unveils insights into viral infection dynamics, notably implicating them in pivotal processes like actin binding and focal adhesion. Our findings establish a robust foundation for the development of antiviral therapies, with continued investigation into shared RNA motifs essential for effectively combating emerging viral threats. This research paves the way for the advancement of antiviral therapy development, offering promising avenues for addressing the evolving landscape of infectious diseases.

The thesis itself (up to 3 pages of text) should be attached as a separate file via the "Attachments" form (the buttons are located below this form on this page).
Guidelines for the thesis layout can be found here:
https://bgrssb.icgbio.ru/2024/abstracts/ (in English)
https://bgrssb.icgbio.ru/2024/ru/abstracts/ (in Russian)