Accepted_test

HSPA8 gene polymorphisms and the risk of severe COVID-19

Authors:
Karpenko Andrey, Department of Anesthesia and Critical Care, Institute of Continuing Education, Kursk State Medical University, 305041 Kursk, Russia; Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia
Kobzeva Ksenia, Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia
Sergeeva Vera, Department of Anesthesia and Critical Care, Institute of Continuing Education, Kursk State Medical University, 305041 Kursk, Russia
Bushueva Olga, Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia; Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 305041 Kursk, Russia

Abstract ID: 413

Event: BGRS-abstracts

Sections: [Sym 4] Section “Human population genomics/genetics”

This study investigates the role of polymorphic variants within the HSP70 family member HSPA8 in influencing the severity of COVID-19 among individuals in Central Russia. With COVID-19 presenting varying degrees of severity and significant health implications worldwide, understanding genetic factors contributing to disease severity is crucial. Through a comprehensive analysis involving genotyping of HSPA8 SNPs in over a thousand individuals, the study reveals notable associations. Specifically, the SNP rs1461496 HSPA8 is linked to an increased risk of severe COVID-19 in older patients, alongside implications in clotting dynamics and immune responses. Functional annotation of this SNP elucidates its involvement in critical pathways underlying COVID-19 pathogenesis. Additionally, the SNP rs1136141 HSPA8 demonstrates associations with disease severity in younger patients and immune system regulation, highlighting its potential role in COVID-19 outcomes. These findings underscore the significance of HSPA8 polymorphisms as novel genetic markers for severe COVID-19 risk in the Central Russian population.