Section “Regulatory genomics”

The section “Regulatory genomics” of the symposium “Genomics, transcriptomics and bioinformatics” is devoted to modern advances in the research of mechanisms of regulation of gene expression in pro- and eukaryotes, based on the synergy of high-throughput computational and experimental technologies.

The central questions of the section “Regulatory genomics” include:

• new methods of bioinformatics and computational biology for studying mechanisms of regulation of gene expression at various hierarchical levels of molecular genetic systems functioning: transcription, splicing, translation;
• study of the mechanisms of regulation of gene activity in pro- and eukaryotes on the basis of bioinformatic analysis of results of high-throughput omics experiments, including methods of sequencing RNA and DNA molecules of single cells;
• bioinformatics and computational biology algorithms, from assembly and annotation of genomes and transcriptomes to the search for regulatory elements of genomes and identification of the regulatory role of non-coding RNAs;
• analysis of regulatory sequences and regulatory elements of genomes/transcriptomes; prediction of gene expression patterns using machine learning methods, including neural networks;
• creation of databases/knowledge bases/atlases of molecular phenotypes of organisms, cells, tissues and developmental stages;
• reconstruction of regulatory gene networks and functional annotation of variability of regulatory regions of genomes to assess individual predisposition to pathologies, search for new therapeutic targets, optimization of gene therapy in medicine, and control gene networks to create promising biotechnological producers.