Development of Inhibitors for the E. coli LpxC Protein to Overcome Antibiotic Resistance in Gram-Negative Bacteria

Krylova T.V.¹, Kshondzer T.A.², Nikitina T.V.³, Sotnichenko E.D.^4*, Karpova L.A.⁵, Anashkina A.A.⁶

¹ Ryazan State Medical University, Ryazan, Russia;
² Institute of Pharmacy, Sechenov University, Moscow, Russia;
³ Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia;
⁴ Institute for Digital Biodesign and Modelling of Living Systems, Sechenov University, Moscow, Russia;
⁵ Saint Petersburg Chemical and Pharmaceutical University, Saint Petersburg, Russia;
⁶ Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia