The symposium serves as an interdisciplinary forum for presenting and discussing current advances and new knowledge in medical, population, and evolutionary human genomics/genetics, based on the synergy of precision medicine methods, omics technologies, anthropology, archaeology, and computational/information approaches. The symposium program will comprise two thematic tracks.
The central topics of the first track, “Medical Human Genomics/Genetics,” include:
- molecular diagnostics, therapy, and epidemiology of hereditary diseases;
- functional genomics and modeling of genetic processes and hereditary human diseases;
- multi-omics approaches to studying the hereditary component of multifactorial diseases;
- issues in the genetics and genomics of human ontogenesis (development).
Topics addressed within the second interdisciplinary track, “Population and Evolutionary Human Paleogenomics/Paleogenetics,” which draws on methods from paleogenetics, paleogenomics, ethnogenomics, archaeology, anthropology, linguistics, and related fields, include:
- reconstruction of early stages of the evolutionary history of human ancestors, their dispersal across the planet, and their role in the emergence of modern humans;
- reconstruction of the genetic diversity of ancient Homo groups that contributed to the genetic makeup of present-day humanity (Neanderthals, Denisovans, and early Homo sapiens), including elucidation of evolutionary relationships among species/populations of ancient humans and the processes of their hybridization;
- studies of the genetic structure and genetic history of temporally distinct populations of modern humans based on analyses of variability in a broad range of phylogenetically and phylogeographically informative genetic markers (mitochondrial DNA, the Y chromosome, other nuclear-genome markers, including whole-genome analyses), as well as analyses of the human epigenome, transcriptome, and metagenome. Within this track, particular attention is paid to migration processes at different scales and to the molecular-genetic and cultural mechanisms by which human groups adapt to diverse natural environments and ecological niches;
- the genetic history of the Indigenous populations of the Russian Federation and adjacent regions from antiquity through the Middle Ages and the Modern period: reconstruction of key stages and population-genetic processes that shaped the ethnocultural and genetic landscape of today’s population of Russia;
- investigation of the genetic history of cultivated plants and domestic animals, including their domestication, dispersal, and changes in genetic composition, considered in the context of the genetic history of human populations.