Accepted_test

The gene network of cellular response to Terahertz radiation based on the metabolomic data analysis

by Aelita A. Makarova | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia

Abstract ID: 120

Event: BGRS-abstracts

Sections: [Sym 2] Section “Reconstruction computational analysis and modeling of gene networks and metabolic pathways”

In connection with the development of terahertz (THz) radiation applicative technologies, it is necessary to investigate its effects on living organisms. Studies based on the omics data analysis reported that THz radiation may disturb a number of biological processes, in particular, the metabolic processes occuring in mitochondria. Analyzing the results of LC-MS/MS metabolic screening we obtained 40 metabolites that were significantly altered in the THz-irradiated human melanoma cells. The gene networks approach revealed the potential mechanisms of cellular metabolic profile alterations in response to THz-radiation exposure. We suggested the hypothesis that THz radiation acts upon mitochondrial lipid rafts, leading to the disrupted regulation of transport and conversion of metabolites.