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CRISPR/Cas genome engineering for cancer drug developments
Advancements in genome engineering have paved the way for new possibilities in biomedical science. One of the most promising areas of research is the creation of cellular models for diseases such as oncology and genetic disorders. The vast range of genome manipulations available, including base editing and prime editing CRISPR platforms, provides practically unlimited options for modeling known cancer driver mutations. This has resulted in the development of new drug candidates. The industrial production of cellular models with high-throughput screening capabilities can solve the pharmaceutical industry's slow drug development problem. In this context, examples of cellular model engineering will be presented and discussed.