Accepted_test

Sequence-based computational protein analysis of the MDR pump AcrAB-TolС from Escherichia coli.

by Karakozova M. | Nazarov P.A. | Moscow State University | Moscow State University

Abstract ID: 170

Event: BGRS-abstracts

Sections: [Sym 3] Section “Structural biology of proteins nucleic acids and membranes”

Enter brief annotation of your abstract in this text form (around 250 words)

Multidrug-resistance (MDR) pumps play a vital role in safeguarding bacteria against antibiotics. MDR pumps provide a foundation for non-specific protection of bacteria and are classified into six families of MDR pumps. One of the most extensively researched MDR pumps is the Escherichia coli AcrAB-TolC pump.Were analyzed 8383 TolC protein sequences, 6239 AcrA protein sequences, 3561 AcrB protein sequences.Having analyzed all known sequences of the AcrAB-TolC pump proteins, we found that the use of a bioinformatics approach to sequence analysis leads to incorrect results due to the quality of the database. Almost every sequence required preliminary validation, which changes the analysis pipeline

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