Accepted_test

Sequence-based computational protein analysis MDR pumps for use in epidemiology and drug design.

by Nazarov PA | Moscow State University

Abstract ID: 171

Event: BGRS-abstracts

Sections: [Sym 3] Section “Pharmacology cheminformatics and chemical biology”

Enter brief annotation of your abstract in this text form (around 250 words)

Antibiotic resistance is a pressing problem in modern healthcare. Attempts to predict the effect of a drug on specific strains usually do not lead to positive results. We chose to model MDR pump genes known for their variability. Multidrug-resistant (MDR) pumps are essential for protecting bacteria from antibiotics. These pumps offer a basis for the non-specific defense of bacteria and are categorized into six families of MDR pumps.

Using molecular microbiology, we validate data obtained through sequence analysis. Using molecular biology methods, strains will be created to create pathogen resistance systems in the laboratory. Using molecular docking, we study how the mutation process can affect the antibacterial substances we are developing.

We have developed a pipeline for analyzing pump sequences. This allows us to predict resistance to the antibiotics we are developing based on the primary structure of a set of certain bacterial pump genes.

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