Accepted_test

he family of hydrolase enzymes, phosphopolypases type A2, is widely known for having many important biological functions. They are involved in the basic biochemical reactions of humans and most other organisms [1]. For the first time, FA2 was made public as cytotoxins of snake venom and enzymes of pig pancreatic juice. At the moment, the antiparasitic properties of these enzymes have become widely known [2]. Flatworms were also the object of our research. Parasitic flatworms are one of the most common types of helminths of humans and animals in Russia. And prolonged illness (for example, opisthorchiasis) leads to carcinogenesis [3]. At the moment, there is only scattered knowledge about FA2 flatworms. It is unknown exactly what functions the FA2 of parasitic flatworms performs. However, there are studies that have shown that FA2 can act as a parasite disguise in the host body [4]. The aim of the work is to search for genes and abstract the functions of phospholipase A2 proteins in flatworms.

These results provide a better understanding of the relationship between FA2 diversity and the specific lifestyle of flatworms, which may have important immunological and evolutionary implications.

The study was supported by the Kurchatov Genomic Center of the ICG SB RAS (project No. 075-15-2019-1662): development of the OrthoDom method for orthologs identification.