Accepted_test

Db/db mice as diabetes genetic model;effect of trehalose, comparative study of liver, heart and brain

by Korolenko T.A. | Scientific Research Institute of Neuroscience and Medicine,Novosibirsk

Abstract ID: 184

Event: BGRS-abstracts

Sections: [Sym 7] Section “Animal genetic models of human pathologies on vertebrates and invertebrates”

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The aim of study was evaluating effect of autophagy inducer -trehalose - on autophagy in different organs - liver, heart and brain and intracellular lipids storage. According to morphometric electron microscopic study trehalose consumption decreased body weight of db/db mice with obesity compared with controls (C57BL/6 mice) and db/db mice (drinking plain water),whereas trehalose drinking decreased also serum glucose level, glycated hemoglobin. In hepatocytes of db/db mice compared to the control (C57BL/6 mice) there was higher content of large lipid inclusions and convoluted annular mitochondria; increased lipids were registered in heart and brain cells, autolysosomes were shown with lipid inclusions. Autophagy activation by trehalose had positive effects in db/db mice via possibly increased lipohagy.This effect seems to be promising for prevention of serious diabetes complications (heart and brain damage), and therapy of disease.

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