Accepted_test

Identification of Shared and Distinct Genetic Variants Associated with Type 2 Diabetes Mellitus and Gestational Diabetes Mellitus

by Nataliia Sergeevna Karpova | Dmitrenko Olga Pavlovna | Nurbekov Malik Kubanychbekovich | Federal State Budgetary Scientific Institution “Research Institute of General Pathology and Pathophysiology”, Moscow, Russia | Federal State Budgetary Scientific Institution “Research Institute of General Pathology and Pathophysiology”, Moscow, Russia | Federal State Budgetary Scientific Institution “Research Institute of General Pathology and Pathophysiology”, Moscow, Russia

Abstract ID: 200

Event: BGRS-abstracts

Sections: [Sym 9] Section “Molecular Pathology, Diagnostics, and Therapeutics”

Gestational diabetes mellitus (GDM) is the most common extragenital pathology of pregnancy and represents a serious medical and social problem, increasing the incidence of adverse pregnancy outcomes for both the mother and the fetus. Previous studies have shown that some genetic loci that predispose to the development of type 2 diabetes mellitus (T2DM) may also predispose to GDM. Therefore, the aim of this study was to search for common and unique genetic variants associated with T2DM and GDM, followed by analysis of selected polymorphisms to discover key genes and pathways involved in the development of GDM and T2DM.

The bioinformatics analysis revealed associations of polymorphisms unique to GDM and common to T2DM and GDM. Most of the analyzed polymorphisms have been practically unstudied. The localization of polymorphisms in genes whose protein products function together in common molecular pathways opens up prospects for both further study in case-control studies and for the development of new targeted therapies.