Accepted_test

PARP3 is a potential participant in the regulation of chroma-tin structure

by Alexander Andreevich Ukraintsev | Mikhail Mikhailovich Kutuzov | Ekaterina Anatolievna Belousova | Olga Ivanovna Lavrik | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia

Abstract ID: 237

Event: BGRS-abstracts

Sections: [Sym 11] Section “DNA replication and repair”

In a cell, DNA is contained in a highly organized protein-nucleic acid complex - chromatin. The first level of DNA packaging within chromatin is the nucleosome, a complex in which DNA is wrapped around histones. DNA-dependent proteins of the ARTD family - PARP1, PARP2, PARP3 - are actively involved in many cellular processes associated with the storage and transmission of hereditary information. However, little data has been accumulated on the nature of the interaction of the PARP1/2/3 proteins with the nucleosome. The goal of the work is to study the effect of these three proteins on the structure of the nucleosome using atomic force microscopy (AFM).