Accepted_test

Enter brief annotation of your abstract in this text form (around 250 words)

Until now, up to 40% of PTSD patients show resistance to the effects of pharmacological drugs.The presence of such barriers is associated, among other things, with insufficient knowledge of the pathogenesis of PTSD. The purpose of this work is a comprehensive study of the mechanisms of PTSD based on an interdisciplinary approach that combines experimental research with the methodological arsenal of bioinformatics.The results obtained here  indicate the presence of distinct differences between PTSD+ and PTSD- rats not only at the behavioral but also at the neuro chemical, neuro-endocrine, metabolic and molecular levels. The high effectiveness of resveratrol is explained by its ability to correct PTSD-induced disruptions in gene networks through activation of the deacetylase activity of sirtuin 1 (SIRT1).Additionally, resveratrol can correct PTSD by inhibiting 11βHSD-1 activity However, a phenotype of PTSD+ rats resistant to resveratrol was revealed. The results obtained here are consistent with data on the ability of SIRT1 to paradoxically enhance PTSD manifestation through activation of the SIRT1/NHLH2/MAO-A pathway due to insufficient negative control by microRNAs. A diagnostic panel with MAO-A/MAO-B microRNA was also created.

The thesis itself (up to 3 pages of text) should be attached as a separate file via the "Attachments" form (the buttons are located below this form on this page).
Guidelines for the thesis layout can be found here:

https://bgrssb.icgbio.ru/2024/abstracts/ (in English)
https://bgrssb.icgbio.ru/2024/ru/abstracts/ (in Russian)