Accepted_test

Longitudinal physiological and proteomic profiling under psychological assessments: a pilot study

by Gorbunov K.S. | Research Institute for Systems Biology and Medicine (RISBM)

Abstract ID: 263

Event: BGRS-abstracts

Sections: [Sym 10] Section “Neuroimaging and genotyping technologies for the diagnosis of neuropsychiatric disorders; methods of disease correction based on feedback technology; brain-computer interface technologies”

Human behaviour is an integral function of the whole organism. Differences in the human proteome may reflect differences between human states. We have attempted to identify patterns of dynamic changes in the human proteome over several days of observation, in connection with general physiological indicators of human adaptive changes and individual psychological characteristics. We hypothesize that dynamics of a proteomic profile reflects physiological and psychological conditions of an individual, we intend to continue our research for further evaluation of the given proposition.

A pilot longitudinal study was conducted, during which 20 patients were examined with respect to their proteomic states using 228 proteins and physiological conditions (drawn on FCI (Functional Change Index, R.M. Baevskij, 1997) and Kerdo scores) over three days at four time points during the day (with two-hour time lag). Additionally, participants were classified into groups using Pavlovian Temperament Survey (PTS) and The Big Five Inventory (BFI).

It was concluded that dynamics of FCI scores over time is significantly different for two contrasting psychological groups.We hypothesize that dynamics of a proteome profile reflects physiological and psychological conditions of an individual.