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The role of m6A methylation in mRNA of the regulation of translation is currently well-covered. When METLL3 is knockdown (i.d. methylated level decrease), total protein synthesis becomes more sensitive to mTOR inhibitors. This implies that under normal conditions a significant part of mRNA is methylated, and under cap-dependent translation inhibition conditions (e.g., stress inhibiting mTOR kinase activity) it allows mRNA to be effectively translated. However, the issue of the mechanism for working and regulation of the process is still open to settle. According to the general assumption, the eIF3 factor is binding with m6A in the 5'-UTR mRNA, which results in the ribosome planting on mRNA without the cap-structure. However, it is not known how the whole transcriptome show changes in response to the inhibition of the mTOR signal pathway in methylase-free cells (METTL3 or METTL14).

For this study, we are employing NGS sequencing methodologies to examine the influence of m6a modification on translation in the presence of mTOR signaling pathway inhibition.

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