Accepted_test

Analysis of primary pharmacodynamic effects and possible cyto-toxic effects of synthetic peptidomimetics SAMP-1

by Lyubushkina E.M. | Research Institute of Clinical and Experimental Lymрhology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL- Branch of IC&G SB RAS)

Abstract ID: 271

Event: BGRS-abstracts

Sections: [Sym 9] Section “Innovative pharmacology”

Currently, most bacteria are resistant to the main groups of antibiotics, and therefore the search for modern antibacterial agents remains relevant. The new innovative peptidomimetic SAMP-1 is of interest due to the absence of a specific microbial target, which pushes back the possibility of resistance to it in microorganisms. This work presents a microbiological study of antibacterial and antifungal properties of SAMP-1 on validation test strains and determination of its minimum inhibitory concentration. The acute toxicity study was performed on CD-1 line mice under conventional and SPF vivarium conditions. The presence of SPF status did not influence the results of the study. A safe dose range not causing lethal outcome at a single intravenous injection was determined. A semi-lethal dose was found, as well as LD₁₀ and LD₉₀.