Accepted_test

Unlocking DNA methylation with BSXplorer

Authors:
Konstantin Yuditskiy, Institute of Translational Biomedicine, Saint Petersburg State University
Igor Bezdvornykh, Institute of Translational Biomedicine, Saint Petersburg State University
Anastasia Samsonova, Institute of Translational Biomedicine, Saint Petersburg State University
Alexander Kanapin, Institute of Translational Biomedicine, Saint Petersburg State University

Abstract ID: 279

Event: BGRS-abstracts

Sections: [Sym 1] Section “Regulatory genomics”

Bisulfite sequencing detects and quantifies DNA methylation patterns, contributing to our understanding of gene and transposon expression regulation, genome stability maintenance, conservation of epigenetic mechanisms. Despite being a technology of choice to profile DNA methylation for many years now there are surprisingly few lightweight and robust standalone tools available for efficient graphical analysis of data in non-model systems. Graphical representation of methylation data is crucial in exploring epigenetic regulation on a genome-wide scale however this feature is missing in many of existing analytical packages. BSXplorer is a tool specifically developed to assist researchers in explorative data analysis and in visualising and interpreting bisulfite sequencing data more easily.