Accepted_test

Unlocking DNA methylation with BSXplorer

by Konstantin Yuditskiy | Igor Bezdvornykh | Anastasia Samsonova | Alexander Kanapin | Institute of Translational Biomedicine, Saint Petersburg State University | Institute of Translational Biomedicine, Saint Petersburg State University | Institute of Translational Biomedicine, Saint Petersburg State University | Institute of Translational Biomedicine, Saint Petersburg State University

Abstract ID: 279

Event: BGRS-abstracts

Sections: [Sym 1] Section “Regulatory genomics”

Bisulfite sequencing detects and quantifies DNA methylation patterns, contributing to our understanding of gene and transposon expression regulation, genome stability maintenance, conservation of epigenetic mechanisms. Despite being a technology of choice to profile DNA methylation for many years now there are surprisingly few lightweight and robust standalone tools available for efficient graphical analysis of data in non-model systems. Graphical representation of methylation data is crucial in exploring epigenetic regulation on a genome-wide scale however this feature is missing in many of existing analytical packages. BSXplorer is a tool specifically developed to assist researchers in explorative data analysis and in visualising and interpreting bisulfite sequencing data more easily.