Accepted_test

Search for microRNA target genes in human-gut microbiome interactions

by Darya Troshina | Philipp Shoshin | Adelina Stepanova | Yuriy Orlov | Lomonosov Moscow State University, Moscow, Russia | YSMU of the Ministry of Health of Russia, Yaroslavl, Russia | First Moscow State Medical University of the Russian Ministry of Health (Sechenov University), Moscow, Russia | First Moscow State Medical University of the Russian Ministry of Health (Sechenov University), Moscow, Russia

Abstract ID: 284

Event: BGRS-abstracts

Sections: [Sym 9] Section “Gene expression and human diseases”

MicroRNAs are small non-coding RNA molecules that play a key role in the regulation of gene expression at the post-transcriptional level. They complementarily pair with mRNA regions and inhibit their translation, which leads to suppression of gene activity. This work investigates the potential of microRNAs as regulators of the human intestinal microbiome and their interaction with bacterial target genes. The aim of the study is to identify and analyse target genes for a range of microRNAs purported to influence the composition and function of the gut microbiota. Using bioinformatics tools, potential target genes were predicted, revealing key molecular interactions relevant to the maintenance of gut homeostasis and overall human health. The results of this study may contribute to the development of new approaches to correct the microbiota and prevent diseases associated with microbial flora imbalance.