Accepted_test

TCRscape - a tool for simultaneous multimodal gene expression analysis of single T-cells and their clonotypes

by Roman Perik-Zavodskii | Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology (RIFCI)

Abstract ID: 285

Event: BGRS-abstracts

Sections: [Sym 12] Section “Systems theory, big biological data analysis, ontologies and artificial intelligence”

In this work we have created TCRscape - a tool that can simultaneously identify dominant clonotypes and assess the phenotype of antigen-specific TCR T-cells obtained using the BD Rhapsody single-cell analysis system. TCRscape is a convenient and fast tool for screening T-cell receptor clonotypes for a comprehensive list of downstream tasks. The selected T-cell receptor clonotypes can serve as candidates for the development of therapeutic constructs that have the potential to be used in many areas, including the treatment of neoplastic diseases and the modulation of immune responses by Treg cells.