Accepted_test

Identification and description of key genes associated with the pathogenesis of autism spectrum disorders through reconstruction and analysis of gene networks.

by Kolos A.V. | I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Abstract ID: 306

Event: BGRS-abstracts

Sections: [Sym 2] Section “Reconstruction computational analysis and modeling of gene networks and metabolic pathways”

Enter brief annotation of your abstract in this text form (around 250 words)

This research focuses on the identification and description of key genes associated with the pathogenesis of autism spectrum disorders through reconstruction and analysis of gene networks. Utilizing the GeneTrek database and various gene lists associated with ASD, key genes were identified and analyzed using a systems approach. The study reveals a cohesive gene network forming functional clusters, with significant enrichment in synaptic gene ontologies and molecular functions related to neurodevelopmental processes. Notably, genes expressed in presynaptic membranes, chromosomal regions, and glutamatergic synapses play pivotal roles in ASD phenotypes. The findings suggest potential therapeutic pathways for ASD, emphasizing the importance of understanding gene interactions and functions in complex disorders. The study highlights the relevance of the glutamatergic hypothesis in ASD pathophysiology and underscores the significance of gene network analysis in unraveling the complexities of ASD biology for targeted interventions.

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