Accepted_test

The genes and eQTLs to unravel the genetic underpinnings of skin wrinkling and sagging

by Ageeva E. | Khvorykh G. | V.I. Vernadsky Crimean Federal University | National Research Centre “Kurchatov Institute "

Abstract ID: 311

Event: BGRS-abstracts

Sections: [Sym 9] Section “Molecular Pathology, Diagnostics, and Therapeutics”

The skin aging as a prominent indicator of the aging process, influenced by both genetic factors and environmental elements, attracts increasing attention of the researchers last years. Understanding the precise genetic mechanisms underlying skin aging remains challenging. This research aims to identify candidate genes, single-nucleotide polymorphisms (SNPs), and expression quantitative trait loci (eQTLs) involved in skin aging to guide future studies and interventions. Skin aging manifests in various phenotypes, with ethnic populations exhibiting differences in both phenotypes and genetics. The study focuses specifically on skin wrinkling and sagging in individuals of European ancestry. Using open data and bioinformatics approaches, we identified 6 candidate genes of these phenotypes, characterized by eQTLs and possible tagSNPs, These findings can contribute to genetic mechanisms underlying skin aging resulting in translation of GWAS signals into clinical practice.