Accepted_test

Mathematical modeling of AMPK/mTOR signaling system uncovers the causes in differences of hypothalamic neuropeptide expression regulating feeding behavior in slow- and fast-growing chickens

by Анастасия Волянская | ИЦиГ СО РАН

Abstract ID: 313

Event: BGRS-abstracts

Sections: [Sym 2] Section “Reconstruction computational analysis and modeling of gene networks and metabolic pathways”

Mathematical models were constructed to describe the regulation of feeding behavior in the cells of the hypothalamus in chickens with a slow and fast growth rate. The basis for the structural difference between the models was the observed difference in the signaling of the transcription factor FOXO1, which regulates the expression of hypothalamic neuropeptides. Modeling of the dynamics of expression of the concentrations of the hypothalamic neuripeptides NPY and POMC was carried out under conditions of free feeding of chickens, proposed on the basis of the functions of changes in leptin concentrations in chickens with slow and high growth rate. Structural differences in the FOXO1 signaling pathway mediated differences in the dynamics of POMC and NPY concentrations. Broilers showed an increase in POMC concentrations with age, while slow-growing chickens with showed a decrease. This mechanism may explain the difference in feeding behaviour of meat chicken breeds.