Accepted_test

Expression of glutamatergic system genes in rats with stereo-typies and audiogenic epilepsy (PM strain)

by Plekanchuk V.S. | Ryazanova M.A. | Federal research center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia | Federal research center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia

Abstract ID: 343

Event: BGRS-abstracts

Sections: [Sym 5] Section “Population and evolutionary genetics/genomics of wild and domestic animals”

PM strain (an abbrevPM strain (an abbreviation for “pendulum-like movements”) was obtained by selection for increased pendulum-like movements as a model of stereotypies in catatonic syndrome. In addition it has been noticed that PM rats also have a predisposition to seizures caused by audiogenic stimuli. Considering the data on the involvement of the glutamatergic system in the etiopathogenesis of eplepsy and catatonia, the aim of the work was set: to study the expression of the glutamatergic system genes at the transcriptional level of the PM rats brain.The study revealed a high level of Grm2 mRNA in hippocampus and prefrontal cortex ; an increase in the mRNA of Grm5 in the prefrontal cortex; a high level of the Slc1A3 gene mRNA and decrease in the mRNA of the Gad1 gene in the hippocampus of PM rats.The identified changes in the glutamate system genes expression in PM rats brain structures indicate changes in the neurotransmission of glutamate and can affect the level of excitation of these brain structures and electroconvulsive activity. The data obtained may help to identify the mechanisms of development of stereotypical pendulum-like movements and the susceptibility to audiogenic seizures of PM rats.