Accepted_test

Epigenetics and accelerated aging of Far Northern Yakutian populaiton

by Alena Kalyakulina | Igor Yusipov | Elena Kondakova | Mikhail Ivanchenko | Laboratory of Systems Medicine of Healthy Aging, Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia | Laboratory of Systems Medicine of Healthy Aging, Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia | Laboratory of Systems Medicine of Healthy Aging, Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia | Laboratory of Systems Medicine of Healthy Aging, Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia

Abstract ID: 35

Event: BGRS-abstracts

Sections: Section “Genetics and systems biology of aging”

We present the results of the first epigenetic study of the Yakutian population using whole-blood DNA methylation data, supplemented with the comparison to the residents of Central Russia. In particular, we aimed to improve understanding of the mechanism of accelerated aging, development of age-related diseases in extreme climate conditions, as well as adaptation of organism to the cold. Gene set enrichment analysis revealed, among others, geographic region-specific differentially methylated regions associated with adaptation to climatic conditions (water consumption, digestive system regulation), aging processes (actin filament activity, cell fate), and both of them (channel activity, regulation of steroid and corticosteroid hormone secretion). Further, it is demonstrated that the epigenetic age acceleration of the Yakutian representatives is significantly higher than that of Central Russia counterparts. For both geographic regions, we showed that epigenetically males age faster than females, whereas no significant sex differences were found between the regions.