Accepted_test

Glutamate receptors are key components of exciting synapses into a brain. Through structural proteins of postsynaptic density, they form various protein macrocomplexes. It mediated of intermolecular rearrangements and form the functional regulatory networks. The AMPAR is subject to functionally distinct constitutive and regulated clathrin-dependent endocytosis, contributing to various forms of synaptic plasticity. The molecular mechanisms of links synaptic signalling pathways to the AMPARs endocytosis machinery remains elusive. There are different and/or alternative pathways for triggering endocytosis of synaptic receptors, that is under the control of a complexity regulatory network in the dendritic spine interactome.