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Enter brief annotation of your abstract in this text form (around 250 words)

The study delves into the multifaceted roles of ribosomal proteins, particularly ribosomal protein uS3, in breast cancer cells and their potential involvement in exosome-mediated intercellular communication. By investigating the interactions between uS3 and endosomal sorting complex ESCRT proteins HGS and Alix, the research sheds light on the mechanisms underlying the sorting of ribosomal proteins into exosomes. The findings suggest that under conditions of elevated free ribosomal protein levels, ESCRT components HGS and Alix can interact with uS3, potentially facilitating its packaging into exosomes. These interactions were notably enhanced in scenarios mimicking cellular ribosomal stress, where ribosomal assembly is compromised. The study highlights the intricate interplay between ribosomal proteins and exosome biogenesis, offering insights into how these interactions may contribute to cancer progression and metastasis. While the research provides valuable insights into the specific interactions between uS3 and ESCRT proteins in breast cancer cells, further investigations are warranted to elucidate the broader implications of ribosomal protein sorting into exosomes across different cell types and pathological conditions.

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Guidelines for the thesis layout can be found here:
https://bgrssb.icgbio.ru/2024/abstracts/ (in English)
https://bgrssb.icgbio.ru/2024/ru/abstracts/ (in Russian)