Accepted_test

HSP90AA1 gene polymorphisms and the risk of ischemic stroke

by Ksenia Kobzeva | Anna Dorofeeva | Olga Bushueva | Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia | Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia | Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia; Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 305041 Kursk, Russia

Abstract ID: 411

Event: BGRS-abstracts

Sections: [Sym 4] Section “Human medical genomics/genetics”

This study delves into the intricate relationship between genetic variations within the HSP90AA1 gene, part of the HSP90 family, and the susceptibility to and clinical manifestations of ischemic stroke (IS). Given IS's substantial global impact as a leading cause of mortality and disability, understanding the role of heat shock proteins (HSPs), particularly HSP90, is paramount. Through comprehensive genotyping and bioinformatic analysis, the research uncovers significant associations between specific HSP90AA1 polymorphisms and IS risk. Notably, the SNP rs11621560 HSP90AA1 emerges as a key genetic determinant, particularly accentuating IS susceptibility in individuals with low intake of fresh fruits and vegetables. Mechanistically, this SNP's influence on IS pathogenesis is elucidated through its regulation of TRAF3 expression and its impact on various biological processes pivotal in IS progression. Furthermore, the study identifies a distinct association between another HSP90AA1 SNP, rs7155973, and the coagulation parameter INR. Overall, these findings underscore the significance of HSP90AA1 gene polymorphisms as novel genetic markers for IS susceptibility and clinical outcomes.