Accepted_test

Using mass spectrometric analysis, 21 differentially expressed pathogenetically significant proteins were identified in patients with bipolar disorder (BD). These proteins are structural elements of the cytoskeleton and membrane receptors; they are involved in the regulation of DNA synthesis and the cell cycle, differentiation of nerve cells and transport processes across the cell membrane. Using ANOVA analysis, statistically significant differences were found between subgroups of BD patients with current depressive and mixed episodes, as well as with healthy individuals, in the content of Low-density lipoprotein receptor-related protein 2 (LRP2) and dermicidin (DCD). Further, using the Mann-Whitney test, an increase in the level of LRP2 and DCD was detected in BD patients with a current depressive episode in comparison with healthy individuals. This may indicate the launch of protective neuroprotective mechanisms in response to neuronal damage during the pathogenesis of bipolar disorder. A significant increase in actin aortic smooth muscle (a-SMA) was also found in patients with bipolar disorder with a current mixed episode compared to healthy individuals. The neuroprotective effect of DCD, as well as the possible participation of α-SMA in the regulation of NMDA receptor conductivity, allows us to propose these proteins as a potential biomarker of BD with a more detailed study of their pathogenetic role.