Accepted_test

ELF5 SNPs and the risk of severe COVID-19 in Russian population
by Loktionov Alexey | Karpenko Andrey | Kobzeva Ksenia | Sergeeva Vera | Bushueva Olga | Department of Anesthesia and Critical Care, Institute of Continuing Education, Kursk State Medical University, 305041 Kursk, Russia; Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia | Department of Anesthesia and Critical Care, Institute of Continuing Education, Kursk State Medical University, 305041 Kursk, Russia; Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia | Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia | Department of Anesthesia and Critical Care, Institute of Continuing Education, Kursk State Medical University, 305041 Kursk, Russia | Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia; Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 305041 Kursk, Russia
Abstract ID: 419
Event: BGRS-abstracts
Sections: [Sym 4] Section “Genome-wide association studies”

This study delves into the genetic underpinnings of COVID-19 severity by examining polymorphic variants of the ELF5 gene, previously identified by GWAS, in the population of Central Russia. With COVID-19 exhibiting a wide spectrum of clinical outcomes, understanding genetic factors contributing to disease severity is imperative. The research focuses on the impact of ELF5 gene variants, specifically rs7949972 and rs61882275, on COVID-19 severity, leveraging advanced genotyping techniques and thrombodynamics testing. The findings reveal significant associations between rs7949972 ELF5 and reduced COVID-19 severity among individuals with a BMI < 30, highlighting the protective role of this SNP. Additionally, allele A of rs61882275 ELF5 is implicated in delayed clot formation, indicating its potential influence on disease progression. Notably, bioinformatics analysis sheds light on the molecular mechanisms underlying these associations, emphasizing ELF5's involvement in key pathways relevant to COVID-19 pathogenesis. Furthermore, the study elucidates the impact of ELF5 variants on lung function parameters, offering insights into their broader physiological effects. Overall, this research underscores the importance of ELF5 polymorphisms as genetic markers for COVID-19 severity and provides novel insights into the disease mechanisms within the Central Russian population.