Accepted_test

FUT2 Gene Polymorphism in samples of Tuvinians and Rus-sians of Eastern Siberia

by L.E. Tabikhanova | Osipova L. P. | Churkina T. V. | Lichman D. V. | Voronina E. N. | Filipenko M. L. | Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk Russian, Federation | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk Russian, Federation

Abstract ID: 435

Event: BGRS-abstracts

Sections: [Sym 4] Section “Human medical genomics/genetics”

Thus, the allele frequencies of the polymorphic locus FUT2 (rs602662) in Tuvinians and Russians of Eastern Siberia were determined for the first time. The frequencies of polymorphic variants due to the single nucleotide substitution G772A of the FUT2 gene were determined by the real-time polymerase chain reaction method. It was shown that in the Russian sample the frequency of the non-secretory allele -772A is within the frequency range for other Caucasoid populations. The frequency of -772A in the Tuvinian sample is in an intermediate position between Caucasoids and East Asian populations. The statistically significantly reduced frequency of the non-secretory allele -772A of the FUT2 gene in the Tuvinian population may indicate an increased risk of gastrointestinal pathologies in case of H. pylori infection, compared to the Russians.At the same time, the Tuvinian population probably has a reduced risk of chronic pancreatitis. However, to test this hypothesis, additional medical genetic studies are needed in various populations with a large sample size, as well as the study of the frequencies of allelic variants, not only of FUT2, but also of other functionally significant genes.