Accepted_test

Reconstruction of Gene Networks of Differentially Expressed Genes in Brain Structures of Tame and Aggressive Rats Using the ANDSystem Web Service

by Yatsyk Ivan | Novosibirsk State University, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia

Abstract ID: 443

Event: BGRS-abstracts

Sections: [Sym 2] Section “Reconstruction computational analysis and modeling of gene networks and metabolic pathways”

Aggressive behavior in animals has been studied for a long time and occupies a leading position in scientific research on the foundations of behavior. Identifying the genetic determinants of aggressive behavior is of great importance since increased aggressiveness is one of the major problems in social relations in human society. Additionally, heightened aggression is observed in many psychiatric and neurodegenerative diseases, making the task of reducing manifestations of aggression highly relevant.

Hereditary factors play a significant role in the manifestation of aggressive behavior. Modern studies suggest that the aggressive behavior type has a polygenic determination. This work continues the research aimed at studying the genetic determinants of aggressive behavior. The goal of this work is the reconstruction and analysis of gene networks of differentially expressed genes and the computer analysis of the topology of the resulting gene networks using the ANDSystem web service. Common and tissue-specific biological processes were also identified based on gene network analysis for the analyzed brain structures.