Accepted_test

This study presents a novel modular mathematical model of epileptic seizures, developed through the combination and modification of existing epilepsy models.

The constructed model for the first time makes it possible to simulate the dynamics of seizure onset, propagation and termination simultaneously at the cellular and regional levels of brain organization.

At the cellular level, the model calculates the dynamics of AMPA receptor trafficking, changes in intra- and extracellular ion concentrations, membrane depolarization, and other biophysical processes contributing to ictal activity. At the regional level, the model incorporates cellular processes and the overall large-scale brain network structure to simulate local field potentials of brain regions.

It is demonstrated that the dynamics of individual submodels used in the structure of the multilevel model corresponds to the dynamics of the original models, validated by comparison with experimental data conducted by their authors. Theoretical justification of the connections uniting submodels into a unified structure is provided.