Accepted_test

This study investigates the impact of stress on the expression of pro-inflammatory cytokines and glial markers in rat strains with varying levels of excitability. Stress is known to induce neuroinflammation, implicated in anxiety and depression. The research focuses on Interleukin 1 beta (IL-1β) and tumor necrosis factor (TNF) as well as GFAP and Iba1 as glial markers. Using two rat strains with high (HT) and low (LT) excitability thresholds, stress responses were assessed over two time points post-stress exposure. Results reveal strain-specific alterations in cytokine and glial marker expression, with LT rats exhibiting broader changes, indicating heightened stress sensitivity. However, HT rats also exhibit distinct alterations, suggesting significant stress impact. These findings underscore the need for further investigation into strain-specific stress responses for tailored interventions.