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The gut virome of healthy people and patients with ulcerative colitis: diversity and antimicrobial potential

by Valeria Fedorets | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia

Abstract ID: 506

Event: BGRS-abstracts

Sections: [Sym 8] Section “Biotechnology through the lens of the microbiome”

Enter brief annotation of your abstract in this text form (around 250 words)

Studies aimed at comparing the virome of healthy people and patients with various chronic intestinal diseases, such as ulcerative colitis (UC), are becoming increasingly common. Additionally, the problem of growing bacterial antibiotic resistance has become acute, so the issue of searching for new antimicrobial agents is also urgent. Such antibacterial agents can be endolysins, enzymes used by phages to destroy the bacterial cell wall. The purpose of this work was to study the intestinal virome of healthy people and patients with UC, to search for potential endolysin genes and assess their diversity. The results confirm the assumption that the composition of intestinal viral communities changes in chronic inflammatory diseases. In addition, the sequences of 134 potential endolysins with diverse domain structures were discovered in the studied virome data, many of which do not have characterized homologues, and their further study may be a step towards the development of new antimicrobial agents.

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