Accepted_test

Genome-wide association study of aggression level in individuals from the Volga-Ural region

by Anastasiya Kazantseva | Institute of Biochemistry and Genetics of Ufa Federal Research Centre of RAS; Ufa University of Science and Technology; Ufa State Petroleum Technological University

Abstract ID: 519

Event: BGRS-abstracts

Sections: [Sym 7] Section “Neurogenomics and genetics of behavior”

To date no GWAS studies of aggression in non-clinical sample were conducted in Russian individuals. Therefore, the present study aimed to perform GWAS of aggression level in a moderate sample (N = 1422) of young adults from the Volga-Ural region of the Russian Federation.

DNA samples were obtained from University students aged 18-25 years of the Republic of Bashkortostan and the Udmurt Republic (Russians, Tatars, Bashkirs, Udmurts, persons of mixed ethnicity), who were absent of any mental disorder. Genotyping of ~ 650k SNPs in the studied sample was carried out using DNA microarray technology and reagents (Infinium Global Screening Array v3.0 Kit, Illumina). Aggression level was assessed using the Buss-Perry Aggression Questionnaire (BPAQ-29). GWAS of aggression level was performed in Plink v.1.09 , R and GAPIT v.3 package.

GWAS analysis enabled to identify two SNPs associated with individual aggression level , including rs17124581 (p = 1.56x10^-6) and rs114798927 (p = 3.97x10^-6). The rs17124581 is located in the intergenic region neighboring the KCNK10 and SPATA7 genes, and rs114798927 is located near the TNKS and PPP1R3B genes.

In conclusion, for the first time, we identified rs17124581 and rs114798927 as associated with aggression level in mentally healthy young adults from Russia aged 18-25 years, which implicated GWAS framework.