Accepted_test

It is known that physical activity plays an important role in the development and maintenance of a functionally healthy state not only of individual organs, but also of the entire human body. Achievement of the best outcomes in the training process is feasible with a deep insight of not only physiological, but also molecular-genetic mechanisms underlying the body's response to physical exertion. As a result of the study, a modular model describing the adaptation of skeletal muscle to different types of physical exercise was expanded by considering processes both regulating expression of genes encoding enzymes and protein synthesis. The extension of the transcription factor module, along with the addition of the transcription and translation modules for central metabolism’s enzymes facilitates more precise and detailed description of the molecular mechanisms of human skeletal muscle adaptation to various types of physical stress.