Accepted_test

In this work we studied genetic features for syntropic diseases, including common coexisting of bronchial asthma with other allergic/cardiovascular diseases, and dystropy of bronchial asthma and tuberculosis. We used several methodological approaches for study connections between diseases include bioinformatics methods, molecular-genetic methods and statistical methods.

As a result of the study, it was established that the combination of bronchial asthma, both with other allergic diseases (hay fever and atopic dermatitis) and cardiovascular diseases (hypertension), represents unlike phenotypes from their “isolated” forms that differ in their genetic characteristics. It has been revealed that the key pathophysiological mechanisms underlying the unfavorable combination of allergic diseases are associated with genes of the immune system and genes regulating the functioning of the epidermal barrier. The risk of developing concomitant arterial hypertension in patients with bronchial asthma is mainly associated with polymorphisms of the TLR4, CAT, ANG/RNASE4 genes, which determine the importance of inflammation, oxidative stress and neovascularization, as well as, ADRB1, ADRB2, NR3C1, ANXA1 genes, that are targets of drugs that are used of bronchial asthma and arterial hypertension treatment.

A study of genes associated with asthma and tuberculosis showed that infectious and allergic diseases are variants of a single phenomenon caused by inadequate functioning of the immune system based on a common genetic component.