Accepted_test

The synergistic effect of p53 and PARP-1 on the nucleosome

by Daria Koshkina | Nataliya Maluchenko | Antonina Novichkova | Alexey Feovanov | Vasiliy Studitsky | Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia | Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia | Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia | Shemyakin-Ovchinin Institute of Bioorganic Chemistry, Moscow, Russia. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia | Fox Chase Cancer Centre, Philadelphia, Pennsylvania 19111-2497, USA

Abstract ID: 562

Event: BGRS-abstracts

Sections: [Sym 1] Section “Structural-functional organization of genomes and transcriptomics”

Since their discovery, the proteins poly(ADP-ribose) polymerase 1 (PARP-1) and p53 have been extensively studied as key players in numerous biological pathways. They are thought to be responsible for the DNA damage response, differentiation, metabolism, and aging. In addition to their common functions, they interact with each other. However, the details of the synergistic chromatin-reorganizing activity of PARP-1 and p53 are largely unknown.