Accepted_test

Necessary parameters of extruders and RNA polymerase complex for modeling 3D chromatin structure
by Konstantinov V.V. | Lagunov T.A. | Fishman V.S. | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
Abstract ID: 563
Event: BGRS-abstracts
Sections: [Sym 1] Section “Fundamental and applied 3D genomics”

At the moment, quite a lot is known about the three-dimensional structure of chromatin, starting with the influence of SMC complexes (condensins and cohesins) on the domain structure and ending with the activity of RNA polymerases as the main transcription factors. However, the question of their interaction is rather poorly understood. The use of data collected on a model object, lampbrush chromosomes, has allowed us to expand our understanding of the mechanisms of interaction of SMC complexes with Polymerase II.

This study made possible to reproduce a number of previously observed phenomena in chromatin architecture through computer modeling. This speaks in favor of the topological motive mechanism of SMC complexes and gives a more complete picture of their interaction with RNA polymerases.