Accepted_test

Changes in the expression of the Stc transcription factor in the nervous system and muscle tissue increase the healthspan of Drosophila

by Symonenko A. V. | Roshina N. V. | Pasyukova E. G. | National Research Centre “Kurchatov Institute”, Moscow, Russia | National Research Centre “Kurchatov Institute”, Moscow, Russia; Vavilov Institute of General Genetics RAS, Moscow. Russia | National Research Centre “Kurchatov Institute”, Moscow, Russia

Abstract ID: 575

Event: BGRS-abstracts

Sections: Section “Genetics and systems biology of aging”

Increasing healthy lifespan is a crucial goal of research in biology and medicine, with significant implications for the development and enhancement of the well-being of human society as a whole. We consider the nervous and muscular systems, as the most critical systems determining lifespan.

We investigate the impact on lifespan of the expression level of the shuttle craft (stc) gene, which encodes the transcription factor Stc, known to affect the development of motor neuron axons in Drosophila, in these tissues.

We have shown that selective knockdown of the neuronal transcription factor Stc in the embryonic nervous system of Drosophila results in an increased adult healthspan while maintaining a high functional status of the nervous and muscular systems. Additionally, reducing the expression of Stc in muscle cells positively affects lifespan. Potential targets of Stc mediating these effects include several genes involved in nervous system development, as well as the primary muscle protein myosin.