Accepted_test

Investigation of the retinal and cortical vascular barriers' permabillity along the onset and progression of neurodegenerative pathologies in a rat model

by Daniil | IC&G SB RAS

Abstract ID: 577

Event: BGRS-abstracts

Sections: Section “Genetics and systems biology of aging”

Age-related macular degeneration and Alzheimer disease are wide spread neurodegenerative disorders, associated with a dysfunction of blood-retinal and blood brain barriers. Tough their role in pathogenesis of the pathologies is still under investigation. It is known that function of the barriers vitally depends on tight junctions, which in retina and brain include claudin-5 and occludin, both carrying out important role in maintenance of microvascular net’s structure and permeability. In this study we estimated permeability of blood-retinal and cortical blood brain barriers in relation to the levels of occludin and claudin-5 during the progression of Alzheimer’s disease- and age-related macular degeneration-like pathologies in the OXYS rat model of accelerated ageing.