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New insights into the properly folded membrane protein production for structural studies
by Goncharuk Marina | Motov Vladislav | Kot Erik | Kornilov Fedor | Savitskaya Anna | Mineev Konstantin | Arseniev Alexander | Goncharuk Sergey | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia
Abstract ID: 580
Event: BGRS-abstracts
Sections: [Sym 3] Section “Structural biology of proteins nucleic acids and membranes”

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Membrane proteins are involved in many processes in living cells. Their malfunction is associated with diseases, including socially important ones. Despite the significance, the exact way of their function at the molecular level is poorly studied. Partially this takes place because of substantial difficulties in preparation of properly folded samples (i.e. in an active state or in native conformation) for structural and functional investigation. Despite all recent achievements, there is still no general approach to natively folded membrane protein production. To fill this gap in knowledge, here we present three independent strategies: helical membrane protein refolding from organic solvent mixtures, cell-free synthesis of full-length active membrane protein and protein ligation as well as discuss their scope of application.

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