Accepted_test

Effect of Tnf gene knockout on behavior, BDNF expression, and brain serotonin system during long-term administration of dexamethasone
by Skotnikova Anna | Institute of Cytology and Genetics SB RAS
Abstract ID: 587
Event: BGRS-abstracts
Sections: [Sym 7] Section “Neurogenomics and genetics of behavior”

In TNF KO mice, long-term administration of dexamethasone resulted in an increase in Bdnf gene expression in the hippocampus and proBDNF levels in the frontal cortex, as well as a decrease in motor activity, an increase in depression-like behavior and anxiety. In WT mice dexamethasone administration resulted in cognitive impairment along with an increase in proBDNF levels in the frontal cortex.