Accepted_test

Structure of SARS-CoV-2 receptor-binding domain in complex with the virus-neutralizing nanobody sheds light on mechanism of possible viral avoidance of antibody therapy
by Varfolomeeva L.A. | Sluchanko N.N. | Shcheblyakov D.B. | Favorskaya I.A. | Dolzhikova I.V. | Korobkova A.I. | Alekseeva I.A. | Esmagambetov I.B. | Derkaev A.A. | Prokofiev V.V. | Zorkov I.D. | Logunov D.Y. | Gintsburg A.L. | Popov V.O. | Boyko K.M | Federal Research Centre «Fundamentals of Biotechnology», RAS | Federal Research Centre «Fundamentals of Biotechnology», RAS | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation | Federal Research Centre «Fundamentals of Biotechnology», RAS; Faculty of Biology, Lomonosov Moscow State University | Federal Research Centre «Fundamentals of Biotechnology», RAS; National Research Center for Epidemiology and Microbiology named after Honorary Academician N. F. Gamaleya, Ministry of Health of the Russian Federation
Abstract ID: 595
Event: BGRS-abstracts
Sections: [Sym 3] Section “Structural biology of proteins nucleic acids and membranes”

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The obtained structures of RBD:P2C5 complex enable to formulate a putative mechanism of the virus-neutralizing activity of the P2C5 nanobody to earlier SARS-CoV-2 variants and to explain its decreased binding to the Delta and Omicron XBB.1 variants.

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