Accepted_test

From the study of properties to the rational design of struc-tures based on nucleic acids

by Lomzov Alexander | Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia

Abstract ID: 600

Event: BGRS-abstracts

Sections: [Sym 3] Section “Structural biology of proteins nucleic acids and membranes”

Oligonucleotides are widely used in various areas of fundamental and applied research, in biotechnological and biomedical applications. Changing the properties of oligonucleotide to improve their consumer qualities in solving various tasks is carried out by selecting specific nucleotide sequences, and if this is not sufficient, chemical modifications are introduced into the oligomer structure. Such modifications learned to be introduced in various positions of the nucleotide chain: in the nucleobase, sugar or phosphate residue. Moreover, it is possible to completely replace such nucleotide fragments, for example, backbone [1-2]. A large number of such modifications have already been developed, but the demand for new nucleic acid (NA) derivatives remains due to a number of reasons, including protection by patent law, the complexity or inconvenience of synthesis, the high cost of synthetics, etc. This work is devoted to the development of methods of analysis of the physico-chemical properties of oligonucleotide with modified backbone, as well as the developments of approaches and algorithms for prognostic calculation of such properties.