Accepted_test

Developing a standardized methodology to validate epigenetic aging clocks

by Evgeniy Efimov | Dmitrii Kriukov | Ekaterina Kuzmina | Dmitry V. Dylov | Ekaterina E. Khrameeva | Skolkovo Institute of Science and Technology, Moscow, Russia | Skolkovo Institute of Science and Technology, Moscow, Russia. Artificial Intelligence Research Institute, Moscow, Russia | Skolkovo Institute of Science and Technology, Moscow, Russia. Artificial Intelligence Research Institute, Moscow, Russia | Skolkovo Institute of Science and Technology, Moscow, Russia. Artificial Intelligence Research Institute, Moscow, Russia | Skolkovo Institute of Science and Technology, Moscow, Russia

Abstract ID: 633

Event: BGRS-abstracts

Sections: Section “Genetics and systems biology of aging”

Estimating biological age as a surrogate of human health is important for translating potential longevity drugs into clinical practice. Predictors of biological age, so-called aging clocks, are difficult to validate and to compare between each other, as biological age cannot be measured directly. Unfortunately, the data required to perform aging clock validation by their ability to predict patient mortality is extremely difficult to obtain and is unavailable without an authorized access. Therefore, in the absence of such public DNA methylation data, we developed the first systematic methodology to validate aging clocks by testing their ability to demonstrate accelerated aging in a standardized panel of aging-accelerating conditions derived from open access studies.