by Shimansky V.S. | Popov O.S | Klochkovs T.G. | Apalko S.V. | Sushentseva N.N. | Asinovskaya A.Yu. | Mosenko S.V. | Sarana A.M. | Shcherbak S.G. | 1. City Hospital No. 40 of Health Department of the St. Petersburg Kurortniy District Administration, 197706, Sestroretsk, Russian Federation 2. St. Petersburg State University, Government of the Russian Federation, 199034, St. Petersburg, Russian Federation | 1. City Hospital No. 40 of Health Department of the St. Petersburg Kurortniy District Administration, 197706, Sestroretsk, Russian Federation 2. St. Petersburg State University, Government of the Russian Federation, 199034, St. Petersburg, Russian Federation | 1. City Hospital No. 40 of Health Department of the St. Petersburg Kurortniy District Administration, 197706, Sestroretsk, Russian Federation | 1. City Hospital No. 40 of Health Department of the St. Petersburg Kurortniy District Administration, 197706, Sestroretsk, Russian Federation 2. St. Petersburg State University, Government of the Russian Federation, 199034, St. Petersburg, Russian Federation | 1. City Hospital No. 40 of Health Department of the St. Petersburg Kurortniy District Administration, 197706, Sestroretsk, Russian Federation 2. St. Petersburg State University, Government of the Russian Federation, 199034, St. Petersburg, Russian Federation | 1. City Hospital No. 40 of Health Department of the St. Petersburg Kurortniy District Administration, 197706, Sestroretsk, Russian Federation | 1. City Hospital No. 40 of Health Department of the St. Petersburg Kurortniy District Administration, 197706, Sestroretsk, Russian Federation 2. St. Petersburg State University, Government of the Russian Federation, 199034, St. Petersburg, Russian Federation | 2. St. Petersburg State University, Government of the Russian Federation, 199034, St. Petersburg, Russian Federation | 1. City Hospital No. 40 of Health Department of the St. Petersburg Kurortniy District Administration, 197706, Sestroretsk, Russian Federation 2. St. Petersburg State University, Government of the Russian Federation, 199034, St. Petersburg, Russian Federation
Studies dedicated to the analysis of peripheral transcriptomic signatures of COVID-19 are actively being conducted worldwide. Transcriptomic analysis provides an opportunity to assess the molecular response of the body to infection and may assist in identification of potential targets for therapy.
The aim of this study is to perform a differential gene expression analysis to identify a set of regulatory genes that affect key molecular and cellular pathways involved in the pathogenesis of COVID-19.
Based on the results of this study, we have identified a number of differentially expressed genes that potentially explain the more severe progression of COVID-19, as well as several master regulators whose functions and roles in pathways enriched with differentially expressed genes make them potential targets for biochemical and meta-research.
