Accepted_test

Exploring the Interplay Between Reproducibility of Open Chromatin Regions and Transcription Factor Functional Activity
by Semyon Kolmykov | Mikhail Kulyashov | Tatiana Sokolova | Danila Prasolov | Fedor Kolpakov | Department of Computational Biology, Sirius University of Science and Technology, Sirius, Russia | Department of Computational Biology, Sirius University of Science and Technology, Sirius, Russia | Department of Computational Biology, Sirius University of Science and Technology, Sirius, Russia | Department of Computational Biology, Sirius University of Science and Technology, Sirius, Russia | Department of Computational Biology, Sirius University of Science and Technology, Sirius, Russia
Abstract ID: 666
Event: BGRS-abstracts
Sections: [Sym 1] Section “Regulatory genomics”

Enter brief annotation of your abstract in this text form (around 250 words)

Exploring the relationship between transcription factor binding regions (TFBRs) and open chromatin regions (OCRs) is crucial for comprehending gene expression regulation. Currently, there are thousands of publicly available next-generation sequencing (NGS) experiments on transcription regulation, such as ChIP-seq, DNase-seq, ATAC-seq, etc. Despite the enormous variety of experimental conditions, it is possible to identify groups of experiments conducted under the similar conditions. Hence, exploring the reproducibility of regulatory regions across experiments under the similar conditions alongside their functional analyses holds promise in advancing our understanding of transcriptional regulation mechanisms. The primary goal of this study is to assess the positional specificity of TFBRs relative to OCRs and their reproducibility, and to explore how this characteristic relates with the functional activity of TFBRs.

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